ZNet Tech is dedicated to making our contracts successful for both our members and our awarded vendors.
ITIS 16,[43] GRIN 27,[44] WCSP,[45] NCBI,[46] DELTA[19] ) differ on the exact number of genera included in Liliaceae s.s., but generally there are about fifteen to sixteen genera, depending on whether or not Amana is included in Tulipa and Lloydia in Gagea. Flowers are zygomorphic in some genera (Lilium, Hemerocallis). It has also been associated with the head of a spear. WebLiliaceae comprises 50 genera and approximately 600 species of flowering plants with many of them been used as spices and vegetables. and s.s.) to denote the broader or stricter sense of the circumscription respectively, e.g. FIGURE 7.30. Methods of propagation include both sexual and asexual reproduction. Broken down in cooking and food preparation in the gut to produce isothiocyanates and other products. WebThe List of Liliaceae genera has been much reduced by modern molecular phylogenetic based taxonomy.The current taxonomy of Liliaceae treats the family Liliaceae as having Lilies and tulips in particular have had considerable symbolic and decorative value, and appear frequently in paintings and the decorative arts. The genus name comes from the Classical Latin word lilium, "lily", which in turn came from the Greek lerion (). Habitat They are monocotyledonous plants. From the acrid resin of Xanthorrhoea sealing wax is prepared. Tiger Lily. Smilax glyciphylla. Consequently, there are many different accounts of the Liliaceae in the literature and older uses of the term occur commonly. [20] The seeds are dispersed by wind and water. He recognized 133 genera and 1200 species. Endospermic; endosperm horny or cartilagenous. 6, in two words of three each, polyphyllous (Lilium, Tulipa) or gamophyllous (Aloe, Asparagus) and of various shapes; petaloid or sepaloid; imbricate in bud, usually valvate aestivation, perianth may be scarious or membranous. Stunting and distortion of the shoot and leaves are the most severe symptoms but streaking or angular or elliptical spots are more typical symptoms. Smilax, Aloe, Gloriosa, Veratrum, Colchicum, Scilla and Urginea yield useful drugs. Queen's Cup. WebEA202090998A1 EA202090998A EA202090998A EA202090998A1 EA 202090998 A1 EA202090998 A1 EA 202090998A1 EA 202090998 A EA202090998 A EA 202090998A EA 202090998 A EA202090998 A EA 202090998A EA 202090998 A1 EA202090998 A1 EA 202090998A1 Authority EA Eurasian Patent Office Prior art keywords quercetin mol 1. What are the characters Mendel selected for his experiments on pea plant? By Franz J. Nienhaus. Aloe vera is a medicinal plant of Liliaceae which is a monocot family. Which types of bacteria are used in Bt-cotton? Introduction The genus Veratrum consists of about 45 species in the northern regions on the earth, including 14 species in China, which plays an important role in Liliaceae family [1, 2]. Characters of Liliaceae 2. Mottling or striping of the leaves also occurs. The ovary is placed above the attachment of the other parts (superior). [6][38][39][40] Liliaceae fossils have been dated to the Paleogene[41] and Cretaceous[42] eras in the Antarctic. These vary from the large Fritillaria imperialis (crown imperial) available in a number of colours such as yellow or orange, to much smaller species such as Fritillaria meleagris or Fritillaria uva-vulpis with their chequered patterns. The family was first described in the eighteenth century, and over time many other genera were added until it became one of the largest of the monocotyledon families, and also extremely diverse. They can be used raw, sliced for seasoning salads, boiled with other vegetables, or fried with other vegetables and meat. 107.1): Compressed, herbaceous, without nodes and internodes, smooth, greenish brown, aerial, peduncles are erect and fistular. G. Close-up of flower. They are generally used in outdoor gardens and other displays, although in common with many bulbous flowering plants they are often induced to bloom indoors, particularly during the winter months. The Romans knew See Hayashi and Kawano (2000), Patterson and Givnish (2002), and Tamura (1998a,b). 1997 - 2021 Thomas J. Elpel. Tulips first appeared in the decorative arts in Turkey in the thirteenth century and flourished under the Ottomans, in particular in the royal palaces, and was adopted by the Osmans as their symbol. 4. Bulb or short rhizome, cymose umbel, e.g. Modern taxonomic systems, such as the APG which is based on phylogenetic principles using molecular biology, have redistributed many of these genera resulting in the relatively small family that is currently recognised. 600 species. In modern times it appears in many forms, symbolic and decorative, and can be used on compasses to indicate the direction north, as well as the Scouting movement. Species of Veratrum contain the alkaloids jervine, cyclopamine (11-deoxojervine) and cycloposine (3-glucosyl-11-deoxojervine), and these compounds are known to be teratogenic (Keeler, 1984). Family of flowering plants in order Liliales, including lilies, Examples of the four subdivisions of Liliaceae, Flowers actinomorphic or slightly zygomorphic, Meister des Frankfurter Paradiesgrtleins, "Ecological Impacts of High Deer Densities", "Phylogeny, concerted convergence, and phylogenetic niche conservatism in the core Liliales: insights from, "1.4.4 The undifferentiated perianth (perigon)", "3. Sagebrush Sego lily. [21] Major evolutionary clades include the Lilieae (Lilium, Fritillaria, Nomocharis, Cardiocrinum, Notholirion) from the Himalayas about 12mya and the Tulipeae (Erythronium, Tulipa, Gagea) from East Asia at about the same time. This was accompanied by a shift from rhizomes to bulbs, to more showy flowers, the production of capsular fruit and narrower parallel-veined leaves. B. Lilium sp., with erect flower. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". 0 0 Similar questions The fruit is generally a wind dispersed capsule, but occasionally a berry (Medeoleae) which is dispersed by animals. Tamokou, V. Kuete, in Medicinal Spices and Vegetables from Africa, 2017. The structure was established by an X-ray crystallographic investigation. Approximately ten countries produce lilies commercially altogether. Seed collecting and identification - 35. One of these varieties is known as 'Rembrandt', after the Dutch artist of that name. Being the simplest member identified of the 3a-hydroxycyclotryptamines, representing the N-1 methylated skeleton, the structure is of considerable interest not at least for reference purposes. In the Liliaceae only one cyclotryptamine is known. As he saw it, the Liliaceae were already paraphyletic ("catch-all"), being all Liliales not included in the other orders, but hoped that the future would reveal some characteristic that would group them better. However, most of the West African countries as well as Kenya, Tanzania, Uganda, and Zambia are also producers (http://uses.plantnet-project.org/en/Allium_sativum_%28PROTA%29). Our mission is to provide an online platform to help students to share notes in Biology. Atropa belladonna, commonly known as belladonna or deadly nightshade, is a perennial herbaceous plant in the family Solanaceae. Besides its use as a condiment and spice for flavoring and enriching various cuisines, onion has been known for its high medicinal properties for thousands of years (Lawande,2012). I. Fritillaria biflora, chocolate lily, flower. Essential oil from onion contains a heart stimulant, increasing pulse volume and frequency of systolic pressure and coronary flow. By contrast, the Netherlands is the leading international producer, to the extent of 4 billion bulbs per annum. Western false hellebore (Veratrum californicum) fed to ewes on gestation days 10 to 15 caused cyclopian-type teratological effects (Binns et al., 1962, 1964; Shupe and James, 1983). Alline is optically active ([]D+136.3 in CHCl3) but the absolute configuration seems to be undetermined. Thiacremonone, given to db/db mice, significantly reduced body weight and decreased blood triglyceride and glucose levels when compared with controls (Ban etal.,2012). Most of their genera, Lilium in particular, face considerable herbivory pressure from deer in some areas, both wild and domestic. The common cultivated garden plants are Tulipa, Lilium, Gloriosa, Aloe, Ruscus, Dracaena, Asparagus, Yucca, Hemerocallis etc. Research is now being done to examine these glycosides more carefully. Erythronium americanum, trout lily. Photographed in New Zealand. Associated with decreased risk of cancer. Bracteate, pedicellate, complete, actinomorphic, hermaphrodite, hypogynous, trimerous. [4][5], The diversity of characteristics complicates any description of the Liliaceae morphology, and confused taxonomic classification for centuries. It is distributed worldwide. (1st ed. Rhizome with radical leaves, inflorescence a spike, e.g. Calochortus bulbs were eaten by Native Americans and by the Mormon settlers in Utah during starvation. Venation is usually parallel but reticulate in Smilax and Trillium. Tepals 6 in two whorls of 3 each, large, petaloid, polyphyllous, sometimes slightly fused at the base, imbricate aestivation, inferior. Liliaceae are subject to a wide variety of diseases and pests, including insects, such as thrips, aphids, beetles and flies. That means the seed possesses only a single cotyledon. WebA suitable plant regeneration protocol has been developed from scale leaf and bulb scale explants of Scillahyacinthine, a medicinally important plant species belonging to the family liliaceae.The maximum number of shoots (13.2), with average length 6.5 cm, was achieved with medium containing 1.5 mg/l TDZ. [33] Despite establishing this relative degree of monophyly (genetic homogeneity) for the family Liliaceae,[34][35] their morphology remains diverse[7] and there exists within the Liliaceae clade or grouping, a number of subclades (subgroups). The gynoecium is syncarpous, with a superior ovary, 3 carpels, and 3 locules. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. Lambs may also be born with tracheal stenosis. Dracaena, Aloe. Key Words: Flowers with parts in threes. Aloe vera, a member of the Liliaceae family, is a perennial plant with turgid green leaves joined at the stem in a rosette pattern. Mostly herbs (Asphodelus), perennating by rhizome (Aloe), bulb (Lilium, Tulipa, Allium), tree (Dracena), climber (Asparagus, Smilax), xerophytic plants like Yucca, Aloe; cladodes in Asparagus and Ruscus. The roots of Asparagus (H. Satavaer) yields a tonic. The Medeoleae (Clintonia and Medeola) may have appeared in North America but were subsequently dispersed, as may have the Streptopoideae and Calochortoideae. TBV affects color breaking of flowers particularly in late-flowering pink, purple, and red cultivars, while white- and yellow-flowered cultivars are not affected. The Liliaceae are ecologically diverse. Flowers hermaphrodite and actinomorphic. The family evolved approximately 68 million years ago during the Late Cretaceous to Early Paleogene epochs. The Persian word for tulips, lleh (), was borrowed into Turkish and Arabic as lale. Symptoms develop as chlorotic mottle to stripe-mosaic (Figure 59) and leaves may be twisted or show narrowing. LMoV is a potyvirus and was formerly thought to be a strain of TBV, but serological, host range, and molecular investigations have set it apart from TBV as an own species. khasiana, Aletris spicata, Aloe vera var. Fritillaria atropurpurea. [4] Fences as high as 8 feet may be required to prevent them from consuming the plants, an impractical solution for most wild areas. Nevertheless, since then the tulip has become indelibly associated with the Netherlands and all things Dutch. LILIALES. Aloe:. The aqueous extracts of the leaves and the roots showed an anti-implantation activity of 70% and 77%, respectively, while the ethanol extracts of the leaves and roots showed 48% and 61%, respectively. Aloe vera is a succulent plant belonging to family Liliaceae. The inflorescence is a terminal raceme, of a solitary flower, or rarely an umbel. All the extracts have resulted in significant (p<0.05) reduction in the number of implants when compared with their respective controls. Glacier National Park. The development of a phylogenetic approach to taxonomy suggested the Liliales formed some of the earliest monocots. We use cookies to help provide and enhance our service and tailor content and ads. Cultivated in winter for bulbs. ), Sinapis spp. [53][54][55] One of the tulip breaking viruses is also named the Rembrandt tulip-breaking virus (ReTBV).[56][57]. INTERIOR PLANTS Plant FamiliesLamiaceae to Liliaceae. S-allylcysteine significantly improved glucose levels and insulin sensitivity in STZ-induced diabetic rats (Mathew and Augusti,1973; Panickar,2013). This review article includes 195 medicinal plants form various plant families. Distinctive hot, pungent flavour caused by breakdown products. Particularly enigmatic were Clintonia, Medeola, Scoliopus, and Tricyrtis. Figure 58. Allium porrum commonly known as leek, is a vegetable belonging, along with onion and garlic, to the genus Allium. In rats that were made diabetic by a single injection of streptozotocin (STZ), a reduction in hyperglycemia and dyslipidemia was observed with garlic, or with a mixture containing garlic, ginger, and turmeric (Madkor etal.,2011). Chocolate Lily. Hutchinson has excluded many genera which are included by many botanists in the family Liliaceae. The best answers are voted up and rise to the top. These cookies track visitors across websites and collect information to provide customized ads. [30], Many other botanists echoed Lindley's earlier concerns about the phylogeny of the Liliaceae, but various schemes to divide the family gained little traction. I. Zigadenus fremontii. One natural remedy that can be made from the plants and also natural herbs in your herb garden is a headache painkiller called Echinacea. Liliaceae comprises 50 genera and approximately 600 species of flowering plants with many of them been used as spices and vegetables. The Aloe vera leaves are formed by Examples include tulips, onions, lilies, etc. Note nectary at base of tepal. Allium cepa ( Chapter 14) and Allium Other effects of garlic or extracts include reducing blood pressure and total cholesterol and increasing HDL in spontaneously hypertensive rats (Preuss etal.,2001), diabetic rats (Eidi etal.,2006), or normal rats (Mehrzia etal.,2006), improving endothelial dysfunction in diabetic rats (Baluchnejadmojarad etal.,2003), and lowering glucose levels in fructose-fed insulin-resistant rats (Jalal etal.,2007). Gloriosa, Colchicum. J. Calochortus splendens. Flowers arise on the upper surface of phylloclades. Although many Lilium species such as Lilium martagon and Lilium candidum can be obtained commercially, the majority of commercially available lilies represent the products of a very diverse hybridisation program, which has resulted in a separate horticultural classification, including such groupings as Asian, Oriental and Orienpet. The Liliaceae are characterised as monocotyledonous, perennial, herbaceous, bulbous (or rhizomatous in the case of Medeoleae)[7] flowering plants with simple trichomes (root hairs) and contractile roots. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. Sego Lily. whorled, usually sheathing, rarely petiolate, simple, and parallel veined [rarely net-veined]. Important Types. A few examples: garlic, asparagus, chives, shallots, onions, and leeks. By the sixteenth century it was a national symbol, hence the designation "Tulip era", by which time they were becoming of economic importance.[58]. The colorful flowers produce large amounts of nectar and pollen that attract insects which pollinate them (entomophily), particularly bees and wasps (hymenopterophily), butterflies (psychophily) and moths (phalaenophily). [85] However, the name 'lily' has historically been applied to a wide variety of plants other than the genus Lilium. V. Webmedicinal plants as a single dose or in combination with others. Botanical name Family Common name Plant part used Medicinal value Liliaceae Satavari Root High fever, antioxidant, sexual weakness Content Guidelines 2. Deformities of the limbs can occur in lambs if the ewes are exposed on gestation days 28 to 32. Further species were collected from Persia and the spreading Ottoman Empire saw to it that tulip culture also spread. WebAtropa belladona, an important medicinal plant is of the family Solanaceae. Sand Lily. Allium, Agapanthus. and Western China. They are also an economically important product. Engler and Krause divided the family into 12 sub-families as follows: Rhizome or bulb covered with scale leaves and with terminal inflorescence, e.g. In Africa, the main producers include the Mediterranean Northern region as well as tropical Africa mainly including Sudan, Niger, and Tanzania. Some species are poisonous if eaten and can have adverse health effects in humans and household pets. They are monocotyledonous, perennial, herbaceous, often bulbous geophytes. Calochortus apiculatus. Share Your Word File TRV (genus Tobravirus) is another common virus of tulips with an exceptionally wide host range of cultivated and wild plants. Other symbolic meanings include glory, love and birth. LVS does not induce specific symptoms in many cultivars, but reduced growth, small flowers, and lower bulb yields are recorded. subfamilies and tribes. Almost 10 million tons of garlic are produced each year with China, Korea, India,USA, Spain, Egypt, and Turkey being the worlds largest producers (http://www.kew.org/science-conservation/plants-fungi/allium-sativum-garlic). [66], Bulb offsets and tissue culture produce genetic clones of the parent plant and thus maintaining genetic integrity of the cultivars. is a Liliaceae plant which is used to make pesticides. Bulb offsets usually require at least a year before flowering. Looking for life-changing resources? The helobian origin is further supported by the flower construction of Helonias which is similar to the members of Juncaceae. Affinities 5. However, the absence of studies on their chloroplast genomes and chromatography has considerably hindered the study of their evolutionary and phylogenetic relationships. Liliaceae", "The families of flowering plants: descriptions, illustrations, identification, and information retrieval", "Punctuated genome size evolution in Liliaceae", "Chromosome diversity and evolution in Liliaceae", "Camas (Camassia spp.) At that time, the undesirable viral cause of the spectacular flower breaking was not yet known. Allicin was found to possess insulin potentiating effects (Mathew and Augusti,1973). It gives Colchicine. In India, garlic is used to relieve problems, such as coughs and fevers or applied externally to prevent graying of hair andto improve skin conditions, such as eczema and scabies as well as to treat tetanus andlungs inflammation (http://www.kew.org/science-conservation/plants-fungi/allium-sativum-garlic). Tulips (Tulipa) also have a long cultural tradition, particularly in the Islamic world. While predominantly depicted as white, those seen at Akrotiri are red lilies. WebLiliaceae Medicinal Plants. LVX is a potexvirus, which normally does not lead to pronounced symptoms in most cultivars, but enhances symptoms of LSV. The stamens are usually in two groups of three (trimerous) and the pollen has a single groove (monosulcate). Economic importance includes several taxa of value as ornamental cultivars, including lilies, Lilium, and tulips, Tulipa. As the Seljuks Oghuz-Turkic leaders originated from the steppes moved to Persia, and then west, they took tulips with them to Turkey, where many escaped cultivation and became naturalised. Liliaceae is regarded as a typical monocot family and represents the basic monocot stock from which many families have arisen. A variety of Fritillaria species are used as early spring ornamental flowers. Reduction in the number of stamens to 3 (Ruscus). The virus is transferred to the roots specifically adhering to the zoospores of the chytridiomycete Olpidium brassicae. [74] Most Fritillaria (e.g. Photo contributed by Christy Fitzsimmons. (2006), Hayashi and Kawano (2000), Patterson and Givnish (2002), and Tamura (1998a,b), Naturally Occurring Cyclotryptophans and Cyclotryptamines, Alkaloids: Chemical and Biological Perspectives, Reproductive and Developmental Toxicology, African Medicinal Spices and Vegetables and Their Potential in the Management of Metabolic Syndrome, http://uses.plantnet-project.org/en/Allium_sativum_%28PROTA%29, http://www.kew.org/science-conservation/plants-fungi/allium-sativum-garlic, Toxicity and Beneficial Effects of Some African Plants on the Reproductive System, Toxicological Survey of African Medicinal Plants. Copyright 2023 Elsevier B.V. or its licensors or contributors. The Netherland produces about 2,200 million lily bulbs annually, of which 96% is used domestically and the remainder exported, principally within the European Union. It was also shown that garlic extracts prevent oxidative stress and vascular remodeling in rats fed with sucrose in drinking water (Vazquez-Prieto etal.,2010). [64] Calochortus (mariposa lily) may be sold as a mixture or as cultivars.[65]. JUNE: Lilies", "How A Turkish Blossom Enflamed the Dutch Landscape". Liliaceae Medicinal Plants. 6. Placentation is axile. Many of these countries export bulbs as well as supplying the domestic market. Disporum smithii. Other viruses, reported to naturally infect lilies are ArMV, TRSV, ToRSV, CMV, TRV, TSWV, TMV, and SLRSV. Tepals 6, in 2 whorls of 3 each, gamophyllous, united at the base, white, inferior. These toxins include scopolamine and hyoscyamine, which GI. Retrieved 29 January 2014. Plants in this family have evolved with a fair amount of morphological diversity despite genetic similarity. Cardiocrinum). [8] The flowers may be arranged (inflorescence) along the stem, developing from the base, or as a single flower at the tip of the stem, or as a cluster of flowers. We concentrate on virus diseases of the genera Tulipa and Lilium, as they represent large genera with economically very important ornamentals. Approximately ten other countries produce commercial tulips, largely for the domestic market. Spiritual uses have been assigned to garlic; in fact, it was reported that garlic could be worn, hung in windows, or rubbed on chimneys and keyholes to ward off vampires. Smilax. Consequently, many sources and descriptions labelled "Liliaceae" deal with the broader sense of the family. Most species are grown from bulbs, although some have rhizomes. [29] Over time the family became increasingly broad and somewhat arbitrarily defined as all species of plants with six tepals and a superior ovary, eventually coming to encompass about 300genera and 4,500species within the order Liliales under the Cronquist system (1981). Asphodelus tenuifolius (H. Paiz) (Fig. WebPlants of the Lily Family. As with the Asparagales, family delimitations of the Liliales have undergone a number of changes in recent years. [83] During World War II, starvation conditions in the Netherlands (Hongerwinter, hunger winter 1944) led to using Tulipa bulbs as food. A. sativum has been and continues to be subject of particular research interests for scientists of various fields with more than 5000 scientific publications recorded in Pubmed, related to the keyword A. sativum (Fig. Tobacco necrosis virus D (TNV-D) causes the so-called Augusta disease, named after the variety in which it was first detected. What do you mean by permeability of membrane? The white lily has long been seen as a symbol of purity, coming to be associated with the Virgin Mary in the Middle Ages, from which came the name Madonna lily (Lilium candidum). Figure 59. Request PDF | Research progress of Ypsilandra thibetica, a medicinal plant of Liliaceae | Ypsilandra thibetica belongs to the family Liliaceae. Fritillaria imperialis, Fritillaria meleagris) bulbs contain poisonous neurotoxic alkaloids such as imperialin (peiminine),[75][76][77] which may be deadly if ingested in quantity, while other species such as Fritillaria camschatcensis and Fritillaria affinis are edible. Like a lily among thorns is my darling among the young women" or the Gospel of Mathew (6, 28) "Consider the lilies of the field, how they grow; they toil not, neither do they spin" to represent beauty. TVX is a member of the genus Potexvirus. Give an example. Breaking symptoms have been described as bars, stripes, streaks, featherings, or flames of different colors on petals (Figure 58). Also fungi, viruses and vertebrate animals such as mice and deer. Fresh onion juice has antibacterial properties due to allicin, disulfide, and cysteine compounds and their interactions; an antiplatelet aggregation effect in human and animal blood has been reported due to regular consumption of onion (Mittal etal.,1974; Baghurst etal.,1977; Lawande,2012). Tankeo etal. Classed as goitrogens, which are naturally occurring substances that can interfere with the function of the thyroid. G. superba (Liliaceae) is a semiwoody herbaceous climber native to tropical Africa [167]. C. Tulipa sp., tulip. Raphide crystals and chelidonic acid are lacking. Foliar vein clearing or intercostal light green stripes may develop as well. Garlic constituents with beneficial effects in reducing risk factors associated with MetS have been identified. L,M. The Liliaceae family was described by Michel Adanson in 1763 and formally named by Antoine Laurent de Jussieu in 1789. Only the, Rudall et al. M. Close-up of basal perigonal gland (base of inner tepal). Since alline has never been synthesized, reisolation and study of the structure, reactions and activity is warranted. [95] Calochortus nuttallii, the sego lily, is the official state flower of Utah. In this article we will discuss about:- 1. In Arabic letters, lale is written with the same letters as Allah, and is used to denote God symbolically. Streaks of darker color may occur on tepals of red flowering varieties, whereas those streaks appear translucent in yellow or white flowers. WebThe following are the major vegetative characteristics of the family Liliaceae. [26][27] Tulips can cause skin irritation due to the presence of tuliposides and tulipalins,[78][79][80] which are also found in the flowers, leaves and stems of Fritillaria. Disclaimer Copyright, Share Your Knowledge This is a question and answer forum for students, teachers and general visitors for exchanging articles, answers and notes. Its origin from Helobieae or its ancestor may be assumed from floral structures and helobial endosperm formation in some of the genera of Liliaceae as Petrosavia, Protolirion. The family has close affinity with Amaryllidaceae from which it can be distinguished by the presence of superior ovary, and absence of corona. C,D. Allium:. These cookies ensure basic functionalities and security features of the website, anonymously. The latter are used, in turn, to meet the demand for bulbs for parks, gardens, and home use and, secondly, to provide the necessary bulbs for cut flower production. Privacy Policy3. Other members of the family used for food include Clintonia (leaves), Medeola (roots), Erythronium (corms), and Fritillaria (bulbs).[84].
Will Wild Birds Eat Coffee Grounds,
Fort Sam Houston Ait Privileges,
Articles M